SemaxAlso known as: Semax acetate, ACTH(4-10) analog, Met-Glu-His-Phe-Pro-Gly-Pro

Mechanism of Action

Semax is a synthetic neuropeptide derived from the ACTH(4-10) fragment. It modulates the expression of neurotrophins such as brain-derived neurotrophic factor (BDNF), and influences neurotransmitter systems including dopamine and serotonin pathways. These actions contribute to enhanced neuroplasticity, cognitive function, and stress resilience. It may promote neuronal survival and repair, and supports neuroregeneration in preclinical models.

Reported Research Benefits

Used predominantly in preclinical neuroscience research to study effects on memory, learning, attention, neuroprotection, mood regulation, and stress adaptation. Investigated as a potential agent for cognitive impairment, ADHD models, post-ischemic brain injury recovery, and mental fatigue.

Dosing Protocol & Reconstitution

Available as lyophilized powder requiring reconstitution with bacteriostatic water. Typical preclinical routes include subcutaneous or intranasal administration. Dosing varies by model but is often in the low microgram to milligram range, with careful titration recommended to optimize experimental outcomes.

Research Notes

Studies indicate Semax enhances cognitive performance, memory retention, and neural plasticity with no evidence of addiction or significant toxicity in controlled settings. The mixed use of intranasal delivery in research allows for rapid central nervous system access. Stability post reconstitution is maintained for up to 60 days refrigerated (2–8°C). Batch purity is independently verified to be ≥99%.

Research Summary

Semax is a heptapeptide analog of the ACTH(4-7) fragment (Met-Glu-His-Phe-Pro-Gly-Pro) approved in Russia for ischemic stroke, cognitive impairment, and optic nerve disease. It upregulates BDNF, NGF, and VEGF expression, enhances dopaminergic and serotonergic neurotransmission, and protects against hypoxic brain injury. Users report improved focus, memory, and executive function.

Side Effects & Safety

Well-tolerated with extensive clinical use in Russia. Intranasal irritation is the most common complaint. May cause mild anxiety or overstimulation at higher doses. Transient headache possible. No systemic toxicity reported.

Stability & Storage

Refer to research notes

Molecular Data

Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
Molecular Formula: C38H53N15O9
Molecular Weight: 738.9 g/mol
CAS Number: 80714-61-0
IUPAC Name: N-[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-amino-4-methylsulfinyl-butyl]amino]-4-methylsulfinylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carboxamide

Primary literature: https://pubmed.ncbi.nlm.nih.gov/?term=Semax+ACTH+nootropic+neuroprotection