PinealonAlso known as: Пинеалон, pinealon tripeptide

Mechanism of Action

Pinealon is a synthetic tripeptide that modulates gene expression and cellular regulatory mechanisms primarily within the central nervous system. It is believed to exert neuroprotective effects by stabilizing neuronal function, reducing oxidative stress, and supporting cellular homeostasis to improve cognitive resilience and healthy brain aging.

Reported Research Benefits

Pinealon is commonly studied for neuroprotection, cognitive function improvement, oxidative stress mitigation, and supporting brain health in aging research. It is popular in preclinical and longevity research targeting neurodegenerative processes and cellular stability.

Dosing Protocol & Reconstitution

Pinealon is supplied as a lyophilized powder typically reconstituted with bacteriostatic water. Standard research doses often involve volumes calculated via peptide calculators to achieve desired molar concentrations. Typical animal study doses range from micrograms to milligrams per kilogram, depending on protocol. No standardized human dosing exists as it is not approved for human use.

Research Notes

Preclinical studies suggest Pinealon improves neuronal stability and promotes resistance to oxidative damage with a favorable half-life suitable for repeated dosing in laboratory models. Research remains preliminary with promising indications in neurodegeneration and aging models.

Research Summary

Pinealon (Glu-Asp-Arg / EDR) is a synthetic tripeptide bioregulator of the pineal gland with neuroprotective and anti-aging properties. Studies in rodents and some human data show it reduces oxidative damage in neurons, improves circadian regulation, and protects against CNS ischemia. Like Epithalon, it was developed from research into peptide bioregulators at the St. Petersburg Institute of Gerontology.

Side Effects & Safety

No significant adverse effects reported in published research. Human trial data is limited primarily to Russian studies. May influence melatonin and serotonin rhythms — timing of administration may matter clinically.

Stability & Storage

Refer to research notes

Molecular Data

Sequence: Glu-Asp-Gly (E-D-G)
Molecular Formula: C15H26N6O6
Molecular Weight: 374.4 g/mol
CAS Number: 218949-56-6
IUPAC Name: L-Glutamyl-L-aspartyl-glycine

Primary literature: https://pubmed.ncbi.nlm.nih.gov/?term=Pinealon+EDR+peptide+neuroprotection+pineal