5-Amino-1MQAlso known as: 5-amino-1-methylquinolinium, 5-amino-1-methylquinoline, 5-Amino-1-methylquinolinium compound

Mechanism of Action

5-Amino-1MQ functions primarily as an inhibitor of the enzyme nicotinamide-N-methyltransferase (NNMT). By inhibiting NNMT, it leads to an increase in intracellular levels of NAD+ (nicotinamide adenine dinucleotide), a critical coenzyme for cellular metabolism and mitochondrial energy production. Elevated NAD+ enhances mitochondrial function, promotes increased ATP production, and stimulates fat oxidation. This mechanism also improves insulin sensitivity and modulates energy homeostasis, contributing to fat loss and preservation of muscle mass during caloric restriction.

Reported Research Benefits

Used in preclinical research focused on obesity, metabolic syndrome, diabetes, aging-related metabolic decline, fat mass reduction, and muscle preservation during caloric deficit. It is studied for effects on glucose metabolism, mitochondrial efficiency, and NAD+-dependent pathways.

Dosing Protocol & Reconstitution

Typically supplied as lyophilized powder for laboratory use. Common lab protocols involve reconstitution in bacteriostatic water and subcutaneous injection in animal models using calibrated syringes to achieve precise dosing. Stability is maintained refrigerated at 2–8°C post-reconstitution, with usage recommended within 60 days. Exact dosing varies by experimental design and species but generally follows preclinical trial standards for NNMT inhibitors.

Research Notes

Preclinical studies demonstrate that 5-Amino-1MQ increases NAD+ availability leading to enhanced mitochondrial efficiency and ATP production. It has shown efficacy in reducing fat mass and improving insulin sensitivity in rodent obesity models without affecting appetite. Research remains in early stages with no human clinical trials currently approved. Stability and purity are confirmed at >99% via independent batch testing (COA).

Research Summary

5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in adipose tissue and linked to obesity and metabolic dysfunction. By blocking NNMT, it elevates intracellular SAM and NAD+ levels, promoting fat cell differentiation arrest and enhancing metabolic rate. Preclinical studies in mice demonstrate significant reductions in fat mass and body weight without changes in food intake.

Side Effects & Safety

Limited human data available. Preclinical studies showed no overt toxicity at research doses. Potential effects on methylation pathways and NAD+ metabolism should be considered. Not approved for human use.

Stability & Storage

Refer to research notes

Molecular Data

Molecular Formula: C10H10N2
Molecular Weight: 162.2 g/mol
CAS Number: 1448101-82-0
IUPAC Name: 5-amino-1-methylquinolinium

Primary literature: https://pubmed.ncbi.nlm.nih.gov/?term=5-Amino-1MQ+NNMT