AHK-CuAlso known as: Alanine-Histidine-Lysine-Copper tripeptide, Copper tripeptide-1, Copper peptide GHK-Cu analogue

Mechanism of Action

AHK-Cu functions by binding copper ions which facilitates cellular communication and skin repair processes. It activates gene expression pathways involved in collagen production, tissue regeneration, and hair follicle stimulation. The copper complex promotes antioxidant effects protecting dermal cells from oxidative stress, stimulates fibroblasts to increase extracellular matrix formation, and enhances hair follicle health by supporting hair root strength and growth.

Reported Research Benefits

Primarily used in preclinical research for topical skin rejuvenation, anti-aging effects, improving skin elasticity, collagen synthesis, and hair follicle stimulation to support hair growth and reduce hair loss. Additionally studied for its antioxidant properties in dermatological and cosmetic formulations.

Dosing Protocol & Reconstitution

Supplied as a powder to be reconstituted with bacteriostatic water for topical application. Typical laboratory use involves topical application on skin or scalp using a precision applicator. Concentrations and dosing frequency vary by study but usually involve controlled topical administration in cosmetic or dermatological models. Stability allows 12 months unopened storage at 2-8°C and 60 days post-reconstitution.

Research Notes

Research indicates that AHK-Cu enhances collagen synthesis and cellular repair mechanisms, showing promising anti-aging benefits in skin. It has been studied in vitro and in animal models for hair follicle stimulation and antioxidant effects, with ongoing studies into its efficacy in preventing hair loss and improving skin quality. The peptide displays a favorable safety profile in preclinical settings with minimal irritation.

Research Summary

AHK-Cu (Ala-His-Lys copper complex) is a copper-binding tripeptide that stimulates hair follicle proliferation and reduces follicle apoptosis. Studies show it activates stem cell factor signaling and prolongs the anagen (growth) phase of the hair cycle. It also exhibits antioxidant and anti-inflammatory properties relevant to scalp health.

Side Effects & Safety

Generally well-tolerated in topical and subcutaneous applications. Excess copper exposure may interfere with zinc absorption at high systemic doses. Injection site reactions are possible. Limited long-term human safety data.

Stability & Storage

Refer to research notes

Molecular Data

Sequence: Ala-His-Lys (AHK)
Molecular Formula: C15H24N6O7Cu
Molecular Weight: 336.86 g/mol
CAS Number: 49557-75-7
IUPAC Name: Copper complex of L-alanyl-L-histidyl-L-lysine

Primary literature: https://pubmed.ncbi.nlm.nih.gov/?term=AHK-Cu+copper+peptide+hair