SelankAlso known as: TkSP, Synthetic tuftsin analog

Mechanism of Action

Selank is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin. It modulates the central nervous system by balancing neurotransmitters such as serotonin and dopamine, influences the GABAergic system, and exhibits immunomodulatory effects. Selank enhances neuroplasticity and regulates stress response by impacting cytokine levels and enhancing endogenous enkephalin activity.

Reported Research Benefits

Preclinical research for anxiety reduction, mood stabilization, cognitive enhancement including memory and concentration, stress response modulation, and neuroimmune interactions. Investigated in animal models for depression, anxiety disorders, and cognitive dysfunction.

Dosing Protocol & Reconstitution

Typically supplied as lyophilized powder to be reconstituted with bacteriostatic water. Research doses vary but commonly administered via subcutaneous or intranasal routes in preclinical models. Storage at 2–8°C after reconstitution is recommended, with stability up to 60 days.

Research Notes

Studies demonstrate anxiolytic and nootropic-like effects without sedative or addictive properties. Shows positive impact on memory, cognition, and immune function in animal models. Its effects are generally transient, reflecting modulation rather than permanent alteration of neurotransmission.

Research Summary

Selank is a synthetic heptapeptide analog of the endogenous tuftsin fragment (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed in Russia. It exhibits anxiolytic effects comparable to benzodiazepines without sedation or addiction potential, modulates BDNF and serotonin levels, and enhances memory and learning in clinical studies. It also has immunomodulatory properties via modulation of enkephalin levels.

Side Effects & Safety

Well-tolerated in clinical use in Russia. No reported dependence, withdrawal, or sedation. Mild nasal irritation with intranasal administration. Some users report initial mild fatigue. Limited long-term data outside Russian clinical system.

Stability & Storage

Refer to research notes

Molecular Data

Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molecular Formula: C142H230N40O42
Molecular Weight: 3767.85 g/mol
CAS Number: 146293-96-2
IUPAC Name: L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolyl-L-glycyl-L-proline

Primary literature: https://pubmed.ncbi.nlm.nih.gov/?term=Selank+anxiolytic+nootropic+peptide