EpitalonAlso known as: Epithalon, Epithalamin tetrapeptide, Ala-Glu-Asp-Gly

Mechanism of Action

Epitalon is a synthetic tetrapeptide that acts primarily by activating the enzyme telomerase, which enables the elongation of telomeres at the ends of chromosomes, thereby promoting cellular renewal and potentially slowing cellular aging. It also influences melatonin production and the regulation of circadian rhythms, supports mitochondrial function, and may reduce oxidative stress. These effects contribute to the peptide's role in DNA repair, neuroprotection, and endocrine regulation.

Reported Research Benefits

Epitalon is commonly researched for its potential to extend lifespan, delay aging processes, promote DNA repair, reduce oxidative damage, regulate sleep-wake cycles through melatonin modulation, and support mitochondrial health. It is applied mainly in experimental anti-aging and regenerative medicine studies, neuroprotection research, and studies of circadian rhythm regulation.

Dosing Protocol & Reconstitution

In preclinical and experimental research, Epitalon is typically used in lyophilized powder form reconstituted with bacteriostatic water. It is commonly administered subcutaneously using micro-syringes in animal models. Dosage ranges vary based on experimental design but are generally in the low microgram to milligram scale per administration. The peptide solution should be stored refrigerated (2–8°C) and used within 60 days after reconstitution.

Research Notes

Laboratory studies demonstrate that Epitalon activates telomerase, improving telomere maintenance, which correlates with slowed cellular aging. It has been shown to protect DNA from oxidative damage and enhance mitochondrial function. Research also supports its neuroprotective and immunomodulatory roles. Its half-life in vivo is relatively short, necessitating repeated administration in research protocols. Many studies report beneficial effects on lifespan extension and improved circadian regulation in animal models.

Research Summary

Epitalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide analog of epithalamin, a pineal gland extract, studied extensively for anti-aging effects. It stimulates telomerase activity, leading to telomere elongation in somatic cells, and regulates melatonin production and circadian rhythm. Long-term studies in animals and some human cohorts suggest reductions in mortality, cancer incidence, and age-related hormonal decline.

Side Effects & Safety

No significant adverse effects reported in multiple Russian clinical trials spanning 15+ years. Potential for altered melatonin rhythm if used during daytime. Theoretical oncological concerns with telomerase activation require long-term monitoring.

Stability & Storage

Refer to research notes

Molecular Data

Sequence: Ala-Glu-Asp-Gly
Molecular Formula: C14H22N4O9
Molecular Weight: 390.35 g/mol
CAS Number: 307297-39-8
IUPAC Name: L-Alanyl-L-Glutamyl-L-Aspartyl-Glycine

Primary literature: https://pubmed.ncbi.nlm.nih.gov/?term=Epitalon+epithalamin+telomerase+aging